The 49ers came into Philly and KO 'ed the Super Bowl Champs

A number of key players were not on the roster, such as Fred Warner, Nick Bosa, Ricky Pearsall, Mykel Williams, Brandon Aiyuk, among others. In the second quarter, George Kittle injured his Achilles. In a game against the defending champions, on the road.

No problem for the San Francisco 49ers. Behind a valiant effort from Brock Purdy, Christian McCaffrey, and an undermanned defense alike, the 49ers upset the Philadelphia Eagles, 23–19.

It was Purdy's 4-yard touchdown pass to McCaffrey that put the visitors ahead for good with under three minutes left, and veteran linebacker Eric Kendricks broke up a fourth-down pass to complete the comeback. Purdy passed for 262 yards, two touchdowns, and two interceptions. 114 yards from scrimmage and two touchdowns went to McCaffrey, while 111 receiving yards and a score went to Demarcus Robinson.

The fourth quarter featured three lead changes. On the first play of the quarter, wide receiver Jauan Jennings' 29-yard touchdown pass to Christian McCaffrey gave the visitors a 17–16 lead. Jennings, who also threw a touchdown pass in Super Bowl LVIII, played quarterback in high school, and Kyle Shanahan picked a perfect time to dip into those skills.

The 49ers will meet the Seattle Seahawks in the divisional round. Seattle beat San Francisco 13–3 in Week 18 to win the NFC West and the No. 1 seed.