49ers' running attack defeated the explosive Chargers 22-16

Kyle Shannahan and the San Francisco 49ers seem to have found a strong one two running tandem with the now healthy Eli Mitchell and newly acquired Christian McCaffrey. The two combined for a total of 127 yards with Mitchell leading the Niners rushing attack, notching 89 yards on the ground on a 4.9-yards-per-carry clip. As for McCaffrey, he logged 77 yards from scrimmage along with a rushing touchdown. Jimmy Garoppolo finished with 240 yards through the air on 19 of 28 passing. Brandon Aiyuk was his go-to target, catching six of his seven targets for 84 yards.

The Chargers came in the game banged up and lost some significant beef on the defensive line. The Chargers battled all throughout the game and the team seemed to lack consistent firepower. Los Angeles started the game off hot but could never sustain that energy. Justin Herbert completed 21 of 35 for 196 yards, a touchdown and an interception. DeAndre Carter led all Chargers pass-catchers with 64 yards through the air.

The 49ers were able to capitalize on the many Chargers injuries the later the game got. The offense was able to impose its will physically, so did the defense. The Niners pass rush started to get home, making things extremely difficult for Herbert. While Herbert wasn't sacked in the second half, he was routinely on the move, flushed out of the pocket and particularly struggled to move the chains.

Next week the 49ers will gear up for an international matchup with the Arizona Cardinals that'll take place at Estadio Azteca in Mexico City next Monday night. As for the Chargers, they'll head back to SoFi Stadium and await the Kansas City Chiefs for an AFC West showdown in prime time.